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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution; although, only in a few cases are genes the primary cause of obesity. [4] [5]
In the United States, the prevalence of obese or overweight adult dogs is 23–53%, of which about 5% are obese; [22] [23] the incidence in adult cats is 55%, [23] of which about 8% are obese. [22] In Australia, obesity is the most common nutritional disease of pets; [24] the prevalence of obesity in dogs in Australia is approximately 40%. [14]
Cavalier King Charles Spaniel with bandaged foot A dog's injured leg. The health of dogs is a well studied area in veterinary medicine.. Dog health is viewed holistically; it encompasses many different aspects, including disease processes, genetics, and nutritional health, for example.
The diet-induced obesity model (DIO model) is an animal model used to study obesity using animals that have obesity caused by being fed high-fat or high-density diets. [1] It is intended to mimic the most common cause of obesity in humans. [2] Typically mice, rats, dogs, or non-human primates are used in these models.
Prentice et al. [17] predicted that the emerging molecular genetics field would ultimately provide a way to test between the adaptive 'thrifty gene' idea and the non-adaptive 'drifty gene' idea because it would be possible to find signatures of positive selection in the human genome, at genes that are linked to both obesity and type 2 diabetes ...
This particular genetic finding doesn’t apply to a large population of people with obesity — only about 1 in 5,000 people have this genetic makeup, Frontini said.
Speakman's work on obesity criticises a long-established theory for obesity known as the thrifty gene hypothesis. His alternative hypothesis proposes that the modern distribution of obese phenotypes arose via the release from predation and random genetic drift: the drifty gene hypothesis.
Obesity in pets is common in many countries. In the United States, 23–41% of dogs are overweight, and about 5.1% are obese. [286] The rate of obesity in cats was slightly higher at 6.4%. [286] In Australia, the rate of obesity among dogs in a veterinary setting has been found to be 7.6%. [287]