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The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells . DAB1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain and during adult neurogenesis .
The spontaneous autosomal recessive scrambler mutation on chromosome 4 causes a deficiency of DAB1, encoding disabled-1, a protein involved in the signaling of the Reelin protein, lacking in the reeler mutant, [3] Dab1-scm homozygous mutants possess a reeler-like phenotype with respect to cell malpositioning in cerebellar cortex, hippocampus, and neocortex.
It was then demonstrated that the mouse disabled homologue 1 gene is responsible for the phenotypes of these mutant mice, as Dab1 protein was absent (yotari) or only barely detectable (scrambler) in these mutants. [26] Targeted disruption of Dab1 also caused a phenotype similar to that of reeler.
January 1, 2025 at 11:53 AM ... But her audience shared concerns about the disabled couple becoming parents. ... 25 of the very best deals from Nordstrom's Half-Yearly Sale: Rothy's, Le Creuset ...
The charity Age UK estimates there are about two million people in England who have unmet care needs - and according to workforce organisation Skills for Care, while 1.59 million people work in ...
Britain's latest plan to overhaul increasingly costly care for older and disabled adults will not be delivered until 2028 at the earliest, the government said on Friday, as it announced a three ...
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain.
An Inverness man has been able to resume his music career despite suffering a stroke that left him unable to speak or walk - by teaching himself to play the guitar one-handed.