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Neomycin/polymyxin B/bacitracin, also known as triple antibiotic ointment, is an antibiotic medication used to reduce the risk of infections following minor skin injuries. [ 1 ] [ 2 ] It contains the three antibiotics neomycin , polymyxin B , and bacitracin . [ 1 ]
Polymyxin B, sold under the brand name Poly-Rx among others, is an antibiotic used to treat meningitis, pneumonia, sepsis, and urinary tract infections. [1] While it is useful for many Gram negative infections, it is not useful for Gram positive infections. [1] It can be given by injection into a vein, muscle, or cerebrospinal fluid or inhaled. [1]
Polymyxin antibiotics are relatively neurotoxic and nephrotoxic, so are usually used only as a last resort if modern antibiotics are ineffective or are contraindicated. . Typical uses are for infections caused by strains of multiple drug-resistant Pseudomonas aeruginosa or carbapenemase-producing Enterobacteri
Neomycin/polymyxin B/hydrocortisone, sold under the brand Otosporin among others, is a medication used to treat otitis externa (swimmer's ear) and certain eye disorders. [2] [3] It consists of the antibiotics neomycin and polymyxin B, and the steroid hydrocortisone. [3] It is used as an ear drop or eye drop. [2] [3]
Bacitracin/polymyxin B (trade name Polysporin among others) is a topical antibiotic cream or ointment. [1] The active ingredients are polymyxin B , bacitracin and occasionally garamycin or gramicidin .
Colistin sulfate may be used to treat intestinal infections, or to suppress colonic flora. Colistin sulfate is also used in topical creams, powders, and otic solutions. Colistin A (polymyxin E1) and colistin B (polymyxin E2) can be purified individually to research and study their effects and potencies as separate compounds.
Neomycin B is the most active component in neomycin followed by neomycin C and neomycin A. Neomycin A is an inactive degradation product of the C and B isomers. [29] The quantities of these components in neomycin vary from lot-to-lot depending on the manufacturer and manufacturing process. [30]
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