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Long-term use has been reported to result in addiction. [39] [42] Attention to the risks of off-label use of propofol increased in August 2009 due to the Los Angeles County coroner's conclusion that musician Michael Jackson died from a mixture of propofol and the benzodiazepine drugs lorazepam, midazolam, and diazepam on 25 June 2009.
A decomposing human body in the earth will eventually release approximately 32 g (1.1 oz) of nitrogen, 10 g (0.35 oz) of phosphorus, 4 g (0.14 oz) of potassium, and 1 g (0.035 oz) of magnesium for every kilogram of dry body mass, making changes in the chemistry of the soil around it that may persist for years.
Its rapid onset of action is due to its high lipid-solubility, rapid redistribution from the brain to other parts of the body, and rapid clearance (20 to 30 mL/kg/minute). [33] Most propofol is conjugated in the liver with pharmacologically inactive metabolites. [ 33 ]
Long after those experiments ended, male doctors remained responsible for determining the treatment of body parts that they did not have or fully understand; many assumed that women’s sexual ...
In the process, metabolites, or byproducts, of the drug are produced, which can linger in our blood, urine (and even in our hair) for long after the initial effects of the drug are felt.
Inaccurate timing of last meal can also increase the risk for aspiration of food, and lead to serious complications. [ 6 ] An important aspect of pre-anaesthetic evaluation is an assessment of the patient's airway , involving inspection of the mouth opening and visualisation of the soft tissues of the pharynx . [ 19 ]
Skeletonization is the state of a dead organism after undergoing decomposition. [1] Skeletonization refers to the final stage of decomposition, during which the last vestiges of the soft tissues of a corpse or carcass have decayed or dried to the point that the skeleton is exposed.
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