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There were an estimated 21.4 million antidepressant drugs items prescribed to patients in England between July and September 2022, according to data from the NHS Business Services Authority.
Taper and conservative switch with a medication-free washout period. ... Changing your dosage or abruptly stopping your medication could cause you ... You can switch your antidepressant treatment ...
Paroxetine, sold under the brand name Paxil among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. [7] It is used to treat major depressive disorder, obsessive–compulsive disorder (OCD), panic disorder, social anxiety disorder, post-traumatic stress disorder (PTSD), generalized anxiety disorder, and premenstrual dysphoric disorder. [7]
Antidepressant discontinuation syndrome is a relatively new phenomenon, being identified and described from 1950s onwards, in parallel with discovery and introduction of modern antidepressant medications, with the first MAOIs, and TCAs introduced from the 1950s onwards and the first SSRIs from the 1980s onwards. [8]
In medicine, tapering is the practice of gradually reducing the dosage of a medication to reduce or discontinue it. Generally, tapering is done is to avoid or minimize withdrawal symptoms that arise from neurobiological adaptation to the drug.
The researchers conducted a review and meta-analysis of 79 trials (44 RCTs and 35 observational studies), which included data from 21,002 individuals — 16,532 discontinuing antidepressants and ...
Very common (10-100% incidence) adverse effects include: Nausea; Sexual dysfunction (including anorgasmia (difficulty achieving an orgasm), erectile dysfunction, genital anaesthesia, ejaculation disorder, loss of libido etc.).
Anafranil (clomipramine) – a tricyclic antidepressant; mostly used to treat OCD Antabuse ( disulfiram ) – inhibits the enzyme acetaldehyde dehydrogenase , causing acetaldehyde poisoning when ethanol is consumed; used to cause severe hangover when drinking; increases liver, kidney, and brain damage from drinking