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A cold sore [a] is a type of herpes infection caused by the herpes simplex virus that affects primarily the lip. [1] Symptoms typically include a burning pain followed by small blisters or sores . [ 1 ]
What are cold sores? Cold sores, also known as fever blisters, can appear on your mouth or lip and are usually caused by oral herpes or herpes simplex virus type 1 (HSV-1). “It’s extremely ...
The Quest for the Next Breakthrough. Cold sores were first described by the Greek philosopher Herodotus in the fifth century BC, and the first modern pharmaceuticals for herpes came two and a half ...
In 2009, acyclovir in combination with hydrocortisone cream, marketed as Xerese, was approved in the United States for the early treatment of recurrent herpes labialis (cold sores) to reduce the likelihood of ulcerative cold sores and to shorten the lesion healing time in adults and children (six years of age and older). [61] [62]
The drug was approved as a cream for oral herpes after clinical trials by the FDA in July 2000. [4] [14] It was shown to shorten the healing by 17.5 hours on average (95% confidence interval: 2 to 22 hours) in a placebo-controlled trial. [15] Another trial showed no effect when treating the infected backs of guinea pigs. [16]
Causes of cold sores. Cold sores are caused by the herpes simplex virus. Outbreaks are triggered by stress, fatigue, illness and other factors. Cold sores treatments. Read more about cold sores ...
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