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  2. Opioid epidemic - Wikipedia

    en.wikipedia.org/wiki/Opioid_epidemic

    With the increase in volume, the potency of opioids also increased. By 2002, one in six drug users were being prescribed drugs more powerful than morphine; by 2012, the ratio had doubled to one in three. [18] The most commonly prescribed opioids have been oxycodone and hydrocodone. The epidemic has been described as a "uniquely American problem ...

  3. Pain ladder - Wikipedia

    en.wikipedia.org/wiki/Pain_ladder

    "Pain ladder", or analgesic ladder, was created by the World Health Organization (WHO) as a guideline for the use of drugs in the management of pain. Originally published in 1986 for the management of cancer pain , it is now widely used by medical professionals for the management of all types of pain .

  4. List of withdrawn drugs - Wikipedia

    en.wikipedia.org/wiki/List_of_withdrawn_drugs

    Diversion, abuse, and a relatively high rate of overdose deaths in comparison to other drugs of its group. This drug continues to be available in most of the world including the US, but under strict controls. Terfenadine (Seldane, Triludan) 1997–1998 France, South Africa, Oman, others, US Prolonged QT interval; ventricular tachycardia [2] [3]

  5. Timeline of the opioid epidemic - Wikipedia

    en.wikipedia.org/wiki/Timeline_of_the_opioid...

    1911 - 1990s According to the FDA's Timeline of Selected FDA Activities and Significant Events Addressing Opioid Misuse and Abuse, before the 1990s, most opioid pain medications were used to manage pain that was either acute or related to cancer. The FDA said that there was an increase in the use of opioids because physicians were not treating ...

  6. Prescription drug overuse - Wikipedia

    en.wikipedia.org/wiki/Prescription_drug_overuse

    Prescription drug overuse or non-medical prescription drug use is the use of prescription medications that is more than the prescribed amount, regardless of whether the original medical reason to take the drug is legitimate. [1] [2] A prescription drug is a drug substance prescribed by a doctor and intended to for individual use only. [3]

  7. Codeine/paracetamol - Wikipedia

    en.wikipedia.org/wiki/Codeine/paracetamol

    Codeine/paracetamol is used for the relief of mild to moderate pain when paracetamol or non-steroidal anti-inflammatory drugs (NSAIDs; such as ibuprofen, aspirin, and naproxen) alone do not sufficiently relieve symptoms. [2] [3] In 2022, it was the 166th most commonly prescribed medication in the United States, with more than 3 million ...

  8. Morphine - Wikipedia

    en.wikipedia.org/wiki/Morphine

    [22] [23] [24] It is a Schedule II drug in the United States, [23] Class A in the United Kingdom, [5] and Schedule I in Canada. [25] It is on the World Health Organization's List of Essential Medicines. [26] In 2022, it was the 139th most commonly prescribed medication in the United States, with more than 4 million prescriptions.

  9. Opioid epidemic in the United States - Wikipedia

    en.wikipedia.org/wiki/Opioid_epidemic_in_the...

    [22] [23] [24] The epidemic began with the overprescription and abuse of prescription drugs. [25] However, as prescription drugs became less accessible in 2016 in response to CDC opioid prescribing guidelines, [26] there was an increase in demand and accessibility to cheaper, illicit alternatives to opioids such as heroin and fentanyl. [27]