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The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy : a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain . [ 1 ]
A main theory behind the cause of Alzheimer’s disease is the build-up of the protein amyloid-beta in the brain. Researchers from the University of Cincinnati provide evidence suggesting it’s ...
An advance in 1984 and 1985 was the identification of Aβ as the protein that forms the cores of plaques. [20] This discovery led to the generation of new tools to study plaques, particularly antibodies to Aβ, and presented a molecular target for the development of potential therapies for Alzheimer's disease. [4] [21] [22] [23]
One of the leading theories behind Alzheimer’s disease is that the toxic accumulation of the proteins beta-amyloid and tau in the brain can cause many of the symptoms related to this condition.
The causes of Alzheimer's disease remain poorly understood. [16] There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an allele of apolipoprotein E. [17] [18] Other risk factors include a history of head injury, clinical depression, and high blood pressure. [1]
Human growth hormone derived from cadavers was linked to Alzheimer's disease in five patients who received injections decades ago, a study in Nature Medicine finds. ... amyloid-beta protein ...
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