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Picamilon (also known as N-nicotinoyl-GABA, pycamilon, and pikamilon) is a drug formed by a synthetic combination of niacin and γ-aminobutyric acid (GABA). It was developed in the Soviet Union in 1969 [ 3 ] and further studied in both Russia [ 4 ] and Japan as a prodrug of GABA.
Picamilon (N-nicotinoyl-GABA) – dietary supplement and prescription drug in Russia Progabide (complex structure) – anticonvulsant Tolgabide (complex structure) – anticonvulsant
4-Fluorophenibut (developmental code name CGP-11130; also known as β-(4-fluorophenyl)-γ-aminobutyric acid or β-(4-fluorophenyl)-GABA) is a GABA B receptor agonist which was never marketed. [1]
SCH-50911 is a selective GABA B antagonist. [1] Its main applications are in pharmacology research. SCH-50911 also acts as an anticonvulsant under normal conditions. SCH-50911 induces acute withdrawal syndrome in GHB-dependent rats, similar to the delirium tremens seen in human alcohol withdrawal, and can precipitate convulsions in GHB-dependent animals.
11-Ketoprogesterone (brand name Ketogestin; former developmental code names Bio 66, U-1258), or 11-oxoprogesterone, also known as pregn-4-ene-3,11,20-trione, is a pregnane steroid related to cortisone (11-keto-17α,21-dihydroxyprogesterone) that was formerly used in veterinary medicine in the treatment of bovine ketosis. [1]
It is known for a long time in Nutropics user community that Picamilon originated in Russia since 1969. The first scientific paper in the West doesn't mean the authors are the inventors of this medicine. Please google "Picamilon 1969" or "site:www.springerlink.com Picamilon 1969" to see some interesting result.
Muscimol (also known as agarin or pantherine) is one of the principal psychoactive constituents of Amanita muscaria and related species of mushroom. Muscimol is a potent and selective orthosteric agonist for the GABA A receptor [3] and displays sedative-hypnotic, depressant and hallucinogenic [citation needed] psychoactivity.
γ-Butyrolactone (GBL) or gamma-butyrolactone is an organic compound with the formula O=CO(CH 2) 3.It is a hygroscopic, colorless, water-miscible liquid with a weak characteristic odor.