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Homeotic genes are genes which regulate the development of anatomical structures in various organisms such as echinoderms, [1] insects, mammals, and plants. Homeotic genes often encode transcription factor proteins, and these proteins affect development by regulating downstream gene networks involved in body patterning.
Homeobox protein Hox-D13 is a protein that in humans is encoded by the HOXD13 gene. [ 5 ] [ 6 ] [ 7 ] This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.
Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene. [5] [6] [7] This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17.
15416 Ensembl ENSG00000120068 ENSMUSG00000056648 UniProt P17481 P09632 RefSeq (mRNA) NM_024016 NM_010461 RefSeq (protein) NP_076921 NP_034591 Location (UCSC) Chr 17: 48.61 – 48.62 Mb Chr 11: 96.17 – 96.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene. Function This gene is a member of the Antp ...
From the example above, if the descendant with genes A1 and B underwent another speciation event where gene A1 duplicated, the new species would have genes B, A1a, and A1b. In this example, genes A1a and A1b are symparalogs. [1] Vertebrate Hox genes are organized in sets of paralogs. Each Hox cluster (HoxA, HoxB, etc.) is on a different chromosome.
The central role of DNA damage and epigenetic defects in DNA repair genes in carcinogenesis. DNA damage is considered to be the primary cause of cancer. [17] More than 60,000 new naturally-occurring instances of DNA damage arise, on average, per human cell, per day, due to endogenous cellular processes (see article DNA damage (naturally occurring)).
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100506311 n/a Ensembl ENSG00000233429 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 7: 27.1 – 27.1 Mb n/a PubMed search n/a Wikidata View/Edit Human HOTAIRM1 (HOX antisense intergenic RNA myeloid 1) is a long non-coding RNA gene. In humans, it is located between the HOXA1 and HOXA2 genes. HOTAIRM1 is expressed in cells of a myeloid lineage, and may ...