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Sertraline, sold under the brand name Zoloft among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [10] used to treat major depression, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder. [11]
BE AWARE that sertraline can potentially have drug interactions with a wide range of other medications, substances or supplements, like alcohol, monoamine oxidase inhibitors (MAOIs), nonsteroidal ...
Paroxetine was the first drug to be approved for social anxiety disorder and it is considered effective for this disorder; sertraline and fluvoxamine were later approved for it as well. Escitalopram and citalopram are used off-label with acceptable efficacy, while fluoxetine is not considered to be effective for this disorder. [ 22 ]
Zoloft is prescribed at several dosages, from 25mg to 200mg per day. Some side effects, including intimate effects, may be more common when Zoloft is used at a high dosage. Switching to a ...
Common SSRIs include Prozac (fluoxetine), Zoloft (sertraline) and Lexapro (escitalopram). Effectiveness and side effect rates can vary between SSRIs. As such, your healthcare provider may suggest ...
Zoloft – an antidepressant of the SSRI class; Zonegran (zonisamide) – an anticonvulsant used to treat other seizures; Zulresso (brexanolone) – a GABA modulator antidepressant; Zyban (bupropion) – same active ingredient as Wellbutrin, but marketed as a smoking cessation aid
Sertraline is the second most potent inhibitor of 5-HT re-uptake which has two very interesting characteristics that distinguish it i.e. sertraline's (1) inhibiting effect on DAT and NET and (2) the binding to sigma-1 (σ 1) receptor in CNS. [18]
Serotonin. A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT).