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Desmoplastic reaction to breast cancer. Desmoplasia refers to growth of dense connective tissue or stroma. [2] This growth is characterized by low cellularity with hyalinized or sclerotic stroma and disorganized blood vessel infiltration. [3] This growth is called a desmoplastic response and occurs as result of injury or neoplasia. [2]
Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. There are two major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse ...
Early stages of glomerulosclerosis may not produce any symptoms, but the most important warning sign is proteinuria, usually discovered in routine medical exams. Losing large amounts of protein may cause swelling in the ankles and an accumulation of fluid in the abdomen. [citation needed]
Atherosclerosis [a] is a pattern of the disease arteriosclerosis, [8] characterized by development of abnormalities called lesions in walls of arteries.This is a chronic inflammatory disease involving many different cell types and driven by elevated levels of cholesterol in the blood. [9]
The skin weighs an average of 4 kg (8.8 lb), covers an area of about 2 m 2 (22 sq ft), and is made of three distinct layers: the epidermis, dermis, and subcutaneous tissue. [1] The two main types of human skin are glabrous skin, the nonhairy skin on the palms and soles (also referred to as the "palmoplantar" surfaces), and hair-bearing skin. [16]
Lung cancer has the highest mortality rate in comparison to other forms of cancer, with the leading cause of development due to smoking. [27] The number of smokers in China is rapidly increasing with tobacco killing approximately 3000 people each day. [27] The diagnosis of lung cancer is most common within the 50–59-year age bracket. [26]
This could indicate that some number of lesions exist, below which the brain is capable of repairing itself without producing noticeable consequences. [1] Another process involved in the creation of lesions is an abnormal increase in the number of astrocytes due to the destruction of nearby neurons. [1] A number of lesion patterns have been ...
The skin gradually becomes fibrotic and adheres to the underlying fascia. [ 6 ] [ 7 ] The symptoms initiate distally in the limbs and progress proximally, sometimes involving the trunk. [ 6 ] Joint contractures of the fingers, elbows and knees can develop secondary to skin involvement and can severely impair physical function.