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Desmoplastic reaction to breast cancer. Desmoplasia refers to growth of dense connective tissue or stroma. [2] This growth is characterized by low cellularity with hyalinized or sclerotic stroma and disorganized blood vessel infiltration. [3] This growth is called a desmoplastic response and occurs as result of injury or neoplasia. [2]
The signs and symptoms of most neoplasms are due to their mass effects caused by the invasion and destruction of tissues by the neoplasms' cells. Signs and symptoms of a cancer causing a paraneoplastic syndrome result from the release of humoral factors such as hormones , cytokines , or immunoglobulins by the syndrome's neoplastic cells and/or ...
Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. There are two major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse ...
Castleman diseases; Other names: Giant lymph node hyperplasia, lymphoid hamartoma, angiofollicular lymph node hyperplasia: Micrograph of Castleman disease showing hyaline vascular features including atrophic germinal center, expanded mantle zone, and a radially penetrating sclerotic blood vessel ("lollipop" sign).
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. [1] Symptoms may include feeling tired, pale skin color, fever, easy bleeding or bruising, enlarged lymph nodes, or bone pain. [1]
Atherosclerosis [a] is a pattern of the disease arteriosclerosis, [8] characterized by development of abnormalities called lesions in walls of arteries.This is a chronic inflammatory disease involving many different cell types and driven by elevated levels of cholesterol in the blood. [9]
This could indicate that some number of lesions exist, below which the brain is capable of repairing itself without producing noticeable consequences. [1] Another process involved in the creation of lesions is an abnormal increase in the number of astrocytes due to the destruction of nearby neurons. [1] A number of lesion patterns have been ...
General treatment regimens have not changed much in the past 30 years, in part due to the lack of randomized clinical trials. [4] Surgery is the treatment of choice if the tumor is determined to be resectable. Curettage is a commonly used technique. [12] The situation is complicated in a patient with a pathological fracture.