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In 2019, the FDA did approve a nasal-spray version of ketamine called esketamine for depression that hadn’t responded to typical antidepressants like SSRIs (“treatment-resistant depression ...
A new study compares ketamine with electroconvulsive therapy in people with treatment-resistant depression. The researchers identify subsets of people who respond better to ketamine and vice versa.
A new slow-release tablet form of ketamine, which can be safely taken at home, could help treat severe depression, according to a clinical trial. ... a ketamine-assisted psychedelic clinic in ...
Esketamine, sold under the brand names Spravato (for depression) and Ketanest (for anesthesia) among others, [10] [12] is the S(+) enantiomer of ketamine. [5] [13] It is a dissociative hallucinogen drug used as a general anesthetic and as an antidepressant for treatment of depression.
After the publication of the NIH-run antidepressant clinical trial, clinics began opening in which the intravenous ketamine is given for depression. [5] [6] This practice is an off label use of IV ketamine in the United States, though the intranasal version of esketamine has been approved by the FDA for treatment of depression [5] [7] In 2015 there were about 60 such clinics in the US; the ...
The effects of psychedelics on neuroplasticity appear to be dependent on serotonin 5-HT 2A receptor activation, as they are abolished in 5-HT 2A receptor knockout mice. [7] Non-hallucinogenic serotonin 5-HT 2A receptor agonists, like tabernanthalog and lisuride, have also been found to increase neuroplasticity, and to a magnitude comparable to ...
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