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Telmisartan, sold under the brand name Micardis among others, is a medication used to treat high blood pressure and heart failure. [3] [6] It is a reasonable initial treatment for high blood pressure. [6] It is taken by mouth. [6] Common side effects include upper respiratory tract infections, diarrhea, and back pain. [6]
Use during pregnancy may harm the baby. [2] Telmisartan works by blocking the effects of angiotensin II while amlodipine works by decreasing calcium ion entry into smooth muscle and heart muscle. [2] The combination was approved for medical use in the United States in 2009. [2]
Telmisartan is, on the other hand, in part metabolized by glucuronidation and olmesartan is excreted as the unchanged drug. [23] Telmisartan is the only ARB that can cross the blood–brain barrier and can therefore inhibit centrally mediated effects of Ang II, contributing to even better blood pressure control. [1]
Losartan, the first ARB. Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT 1) antagonists, [1] also known as angiotensin receptor blockers, [2] [3] angiotensin II receptor antagonists, or AT 1 receptor antagonists, are a group of pharmaceuticals that bind to and inhibit the angiotensin II receptor type 1 (AT 1) and thereby block the arteriolar contraction and ...
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It may be used if telmisartan by itself is not sufficient. [5] It is taken by mouth. [5] Common side effects include dizziness, upper respiratory tract infections, nausea, diarrhea, and tiredness. [2] Severe side effects may include kidney problems, electrolyte problems, and allergic reactions. [2] Use during pregnancy may harm the baby. [2]
The Year Without a Santa Claus, a Christmas special from Jules Bass and Arthur Rankin, Jr., turns 50 this December. The beloved special was adapted from the book of the same name by Phyllis ...
PPARγ (gamma) is the main target of the drug class of thiazolidinediones (TZDs), used in diabetes mellitus and other diseases that feature insulin resistance. It is also mildly activated by certain NSAIDs (such as ibuprofen) and indoles, as well as from a number of natural compounds. Known inhibitors include the experimental agent GW-9662.
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