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Acanthosis nigricans is a medical sign characterised by brown-to-black, poorly defined, velvety hyperpigmentation of the skin. [1] It is usually found in body folds, [2] such as the posterior and lateral folds of the neck, the armpits, groin, navel, forehead and other areas.
Hyperpigmentation can be caused by sun damage, inflammation, or other skin injuries, including those related to acne vulgaris. [1] [2] [3]: 854 People with darker skin tones are more prone to hyperpigmentation, especially with excess sun exposure. [4] Many forms of hyperpigmentation are caused by an excess production of melanin. [4]
Cymbiotika Ultimate Pain Balm is the best pain relief cream for sensitive skin due to its powerful blend of natural ingredients and ability to provide fast and targeted relief for pain and discomfort.
A 2008 Cochrane Library review concluded that LLLT has insufficient evidence for treatment of nonspecific low back pain, [50] a finding echoed in a 2010 review of chronic low back pain. [51] A 2015 review found benefit in nonspecific chronic low-back pain. [15] LLLT may be useful in the treatment of both acute and chronic neck pain. [16]
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The cause of the disease is a haploinsufficiency of the enzyme ATP2C1; [7] the ATP2C1 gene is located on chromosome 3, which encodes the protein hSPCA1.A mutation on one copy of the gene causes only half of this necessary protein to be made and the cells of the skin do not adhere together properly due to malformation of intercellular desmosomes, causing acantholysis, blisters and rashes.
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