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[1] The hypersensitivity syndrome is characterized by a rash that is initially rash that appears similar to measles (morbilliform). [2]: 118 The rash may also be one of the potentially lethal severe cutaneous adverse reactions, the DRESS syndrome, Stevens–Johnson syndrome, or toxic epidermal necrolysis.
ATC code N05 Psycholeptics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. [1] [2] [3] Subgroup N05 is part of the anatomical group N Nervous system. [4]
The benzodiazepines are a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and muscle relaxant properties. Benzodiazepines act as a central nervous system depressant. The relative strength of each of these properties in any given benzodiazepine varies greatly and influences the indications for which it is prescribed.
[3] [41] [42] Immediate medical care is required upon the first signs of these adverse effects. [9] Similarly to other penicillins, amoxicillin has been associated with an increased risk of seizures. [3] [41] [43] [44] Amoxicillin-induced neurotoxicity has been especially associated with concentrations of greater than 110 mg/L. [45]
4.3 6.4 Antagonist α 2B: 21 150 ND: α 2C: 21 48 ND: H 1: 1.3 5.6 Antagonist M 1: 7.9 30 Antagonist M 2: High ND: Antagonist M 3: High ND: Antagonist M 4: Negligible ND – M 5: Negligible ND – Values are K i (nM), unless otherwise noted. The smaller the value, the more strongly the drug binds to the site.
Common side effects include diarrhea, vomiting, and allergic reactions. [5] It also increases the risk of yeast infections, headaches, and blood clotting problems. [2] [6] It is not recommended in people with a history of a penicillin allergy. [2] It is relatively safe for use during pregnancy. [5]
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Pseudoallergy, sometimes known as nonallergic hypersensitivity, is a type of hypersensitivity reaction mostly described in the context of drug allergy. The mechanism is somewhat similar to the type 1 hypersensitivity in the Gell and Coombs classification in that the effector cell is also mast cell .