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The antibody will then react with the drug-protein conjugate and a visible colored line will show up in the test line region of the specific drug strip. [citation needed] Cannabis use is included in the "10-panel urine screen", as well as the "SAMHSA-5", the five drugs tested for in standard NIDA approved drug tests.
These are achieved at lower doses, because many synthetic cannabinoids are more potent than marijuana, and users are often unaware of exactly what they are getting and how potent it is. [55] For example, Δ 9 -THC has an EC 50 of 250 nM at CB 1 and 1157 nM at CB 2 , whereas PB-22 has an EC 50 of 5.1 nM at CB 1 and 37 nM at CB 2 . [ 8 ]
Slang terms include: getting high (generic), being stoned, cooked, or blazed (usually in reference to cannabis), [4] and many more specific slang terms for particular intoxicants. Alcohol intoxication is graded in intensity from buzzed , to tipsy then drunk all the way up to hammered , plastered , smashed , wasted , destroyed , shitfaced and a ...
A 2014 case study based on the toxicology reports and relative testimony in two separate cases gave the median lethal dose in humans at 30 mg/kg (2.1 grams THC for a person who weighs 70 kg; 154 lb; 11 stone), observing cardiovascular death in the one otherwise healthy subject of the two cases studied. [19]
Cannabis use disorder (CUD), also known as cannabis addiction or marijuana addiction, is a psychiatric disorder defined in the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders and ICD-10 as the continued use of cannabis despite clinically significant impairment.
In pharmacology, clearance is a pharmacokinetic parameter representing the efficiency of drug elimination. This is the rate of elimination of a substance divided by its concentration. [ 1 ] The parameter also indicates the theoretical volume of plasma from which a substance would be completely removed per unit time.
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Based on one definition, a drug-like molecule has a logarithm of partition coefficient (log P) between −0.4 and 5.6, molecular weight 160–480 g/mol, molar refractivity of 40–130, which is related to the volume and molecular weight of the molecule and has 20–70 atoms.