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Spondyloarthritis (SpA), also known as spondyloarthropathy, is a collection of clinical syndromes that are connected by genetic predisposition and clinical manifestations. [1] The best-known clinical subtypes are enteropathic arthritis (EA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), and reactive arthritis (ReA). [ 2 ]
Axial spondyloarthritis (also often referred to as axSpA) is a chronic, immune-mediated disease predominantly affecting the axial skeleton (sacroiliac joints and spine). [1] The term itself is an umbrella term characterizing a diverse disease family united by shared clinical and genetic features, such as the involvement of the axial skeleton. [ 2 ]
It is classified as a type of seronegative spondyloarthropathy. Genetics are thought to be strongly involved in the development of psoriatic arthritis. [3] Obesity and certain forms of psoriasis are thought to increase the risk. [3] Psoriatic arthritis affects up to 30% of people with psoriasis and occurs in both children and adults. [3]
Some of these medical conditions include issues like seronegative spondyloarthropathy or ankylosing ... may signal a larger problem known to doctors as inflammatory axial spondyloarthropathy ...
Along with reactive arthritis, psoriatic arthritis, and idiopathic ankylosing spondylitis, this type of arthritis is categorized as a seronegative spondyloarthropathy. [4] Other gastrointestinal disorders like Whipple's disease, celiac disease, and intestinal bypass surgery for severe obesity can also cause joint involvement. The pathogenesis ...
Ankylosing tarsitis of the ankle is a common feature, as is the more classical findings of seronegative ANA and RF as well as presence of the HLA-B27 allele. [13] Primary engagement of the appendicular joints may explain delayed diagnosis; however, other common symptoms of AS such as uveitis , diarrhea, pulmonary disease and heart valve disease ...
Seronegative spondyloarthropathy: Psoriatic arthritis; Ankylosing spondylitis; Rheumatoid arthritis: Felty's syndrome; Juvenile idiopathic arthritis; Adult-onset Still's disease; Crystal arthropathy; Gout; Chondrocalcinosis; Osteoarthritis; Hemarthrosis (joint bleeding) Synovitis is the medical term for inflammation of the synovial membrane ...
Other rheumatological disorders that can cause the features typical for RS3PE include late onset (seronegative) rheumatoid arthritis, acute sarcoidosis, ankylosing spondylitis and other spondyloarthropathies such as psoriatic arthropathy, mixed connective tissue disease, chondrocalcinosis and arthropathy due to amyloidosis. [6] [9]