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Essential features. Begins in the rectum and continues proximally in a continuous pattern to include up to the entire colon (pancolitis) Histologically characterized by active chronic colitis, with inflammation limited to mucosa / submucosa, absence of granulomas and absence of fissuring ulcers.
The pathophysiology of ulcerative colitis involves defects in the epithelial barrier, immune response, leukocyte recruitment, and microflora of the colon. [8] [9] The epithelial barrier has a defect in colonic mucin and possibly tight junctions, leading to increased uptake of luminal antigens.
Ulcerative colitis (UC) is one of the idiopathic forms of inflammatory bowel disease (IBD), sharing this designation with Crohn disease (CD). Ulcerative colitis is a chronic, relapsing...
Ulcerative colitis is one of the two main subtypes of inflammatory bowel disease, along with Crohn's disease. Understanding the clinical and endoscopic features of ulcerative colitis is critical in achieving a timely diagnosis.
Ulcerative colitis is one of the main types of inflammatory diseases that affect the bowel, but its pathogenesis has yet to be completely defined. Several genetic factors and other inflammation-related genes are implicated in mediating the inflammation and development of the disease.
In this review, we focus specifically on these novel developments in the pathogenesis of ulcerative colitis. Keywords: Ulcerative colitis, Inflammatory Bowel Disease, Inflammation, Mucosal Immunology, Pathogenesis. Introduction
Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology with a wide spectrum of disease severity. 1 UC can be complicated by toxic megacolon and colorectal cancer. 2 Pharmacologic management includes aminosalicylates, corticosteroids, purine antimetabolites, and tumor necrosis factor antagonists, used sequentially or ...
The inflammatory bowel diseases (IBDs) are chronic intestinal disorders that are typically categorized as one of two subtypes: Crohn’s disease and ulcerative colitis. 1 Ulcerative colitis...
Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown aetiology affecting the colon and rectum. Multiple factors, such as genetic background, environmental and luminal...
This chapter discusses the histopathology of typical ulcerative colitis (UC) and Crohn's disease (CD), some unusual features or variants of UC and CD, and indeterminate colitis.