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However, in supposedly affected individuals, ingesting histamine through food at levels well below those associated with scombroid poisoning (from eating spoiled fish) can lead to symptoms related to histamine intolerance. [9] [12] [1] [14] In the ICD-11, there is a condition "XM74Y6 Scombroid fish seafood poison", [2] but not "histamine ...
Mast cell activation syndrome (MCAS) is a term referring to one of two types of mast cell activation disorder (MCAD); the other type is idiopathic MCAD. [1] MCAS is an immunological condition in which mast cells, a type of white blood cell, inappropriately and excessively release chemical mediators, such as histamine, resulting in a range of chronic symptoms, sometimes including anaphylaxis or ...
Modafinil and Armodafinil elevate hypothalamic histamine levels, [38] and they are known to bind to the dopamine transporter, thereby inhibiting dopamine reuptake. Modafinil can cause uncomfortable side effects, including nausea , headache , and a dry mouth for some patients, while other patients report no noticeable improvement even on ...
Cholinergic urticaria typically presents with a number of small papular hives all over the body, that involve cutaneous inflammation (wheals) and severe nerve pain, which usually develops in response to exercise, bathing, staying in a heated environment, spicy foods, or emotional stress.
Histamine is not destroyed by normal cooking temperatures, so even properly cooked fish can still result in poisoning. [9] Histamine is the main natural chemical responsible for true allergic reactions, so the symptoms produced are almost identical to a food allergy. [10] [11] Rarely, cheese may be involved. [3]
Histamine N-methyltransferase is encoded by a single gene, called HNMT, which has been mapped to chromosome 2 in humans. [5]Three transcript variants have been identified for this gene in humans, which produce different protein isoforms [6] [5] due to alternative splicing, which allows a single gene to code for multiple proteins by including or excluding particular exons of a gene in the final ...
A typical characteristic of histidinemia is an increase in the blood histidine levels from normal levels (70–120 μM) to an elevated level (290–1420 μM). [3] Further testing includes: observing histidine as well as imidazolepyruvic acid metabolites in the urine. However, neonatal urine testing has been discontinued in most places, with the ...
Mosquito bite allergies are informally classified as 1) the skeeter syndrome, i.e., severe local skin reactions sometimes associated with low-grade fever; 2) systemic reactions that range from high-grade fever, lymphadenopathy, abdominal pain, and/or diarrhea to, very rarely, life-threatening symptoms of anaphylaxis; and 3) severe and often ...