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The coiled-coil motif may also act as a spacer between two objects within a cell. The lengths of these molecular spacer coiled-coil domains are highly conserved. The purpose of these molecular spacers may be to separate protein domains, thus keeping them from interacting, or to separate vesicles within the cell to mediate vesicle transport.
The CARD-CC protein family is defined by an evolutionary conserved "caspase activation and recruitment domain" and a coiled-coil (CC) domain. [1] [2] Coiled-coils (CC) act as oligomerization domains for many proteins such as structural and motor proteins, and transcription factors.
Coiled-coil domain containing 121 (CCDC121) is a protein encoded by the CCDC121 gene in humans. CCDC121 is located on the minus strand of chromosome 2 and encodes three protein isoforms . [ 5 ] All isoforms of CCDC121 contain a domain of unknown function referred to as DUF4515 or pfam14988.
330830 Ensembl ENSG00000159625 ENSMUSG00000031786 UniProt Q8IY82 Q6V3W6 RefSeq (mRNA) NM_001289162 NM_001289163 NM_032269 NM_001042715 RefSeq (protein) NP_001276091 NP_001276092 NP_115645 NP_001036180 Location (UCSC) Chr 16: 57.69 – 57.73 Mb Chr 8: 95.78 – 95.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Coiled-coil domain-containing protein 135, also known as CCDC135, is a ...
The ARM domain, Armadillo/ beta-catenin-like-repeat, is about a 40 amino acid long tandem repeat that forms superhelix of helices. Another feature is that TMCO6 has an Arginine rich region that is within the coil-coiled region. [10] This indicates that the Arg rich area might be an important structural feature of the coiled-coil region.
CCDC130 has two conserved domains and a coiled-coil region. The first is the COG5134 domain which is found to be conserved in cucumbers and likely plays a role in the function of the protein because it is always the most highly conserved region in any multiple sequence alignment. [5] It spans approximately the first 170 amino acids of the protein.
SMCO3 has a single domain, DUF4344 (aa15:221) which is currently uncharacterised. [16] C12orf60 also contains this domain. It contains a single transmembrane region (aa155-175) and has two coiled-coil regions (aa62-92, aa183-207). [17] The C-terminus of SMCO3 contains a KKXX-like motif suggesting endoplasmic reticulum localisation. [18]
67896 Ensembl ENSG00000091986 ENSMUSG00000022665 UniProt Q76M96 Q8R2G6 RefSeq (mRNA) NM_199512 NM_199511 NM_178274 NM_026439 RefSeq (protein) NP_955805 NP_955806 NP_080715 Location (UCSC) Chr 3: 112.6 – 112.65 Mb Chr 16: 44.91 – 44.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Coiled-coil domain-containing protein 80 is a protein that in humans is encoded by the CCDC80 gene ...