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Common side effects include headache, abdominal pain, diarrhea or constipation, and dizziness. [4] Serious side effects may include pneumonia and seizures. [4] [5] Use in pregnancy appears safe but has not been well studied, while use during breastfeeding is not recommended. [1] Famotidine was patented in 1979 and came into medical use in 1985. [6]
When these medications are used long term, the lowest effective dose should be taken. [4] They may also be taken only when symptoms occur in those with frequent problems. [5] Proton-pump inhibitors are named using the suffix "-prazole". There is a purported correlation (but no proven causal link) between the use of PPIs and the risk of dementia ...
Specialty professional organizations recommend that people take the lowest effective PPI dose to achieve the desired therapeutic result when used to treat gastroesophageal reflux disease long-term. [ 20 ] [ 21 ] [ 22 ] In the United States, the Food and Drug Administration (FDA) has advised that over-the-counter PPIs, such as Prilosec OTC ...
The risk of progression from Barrett's to dysplasia is uncertain, but is estimated at 20% of cases. [30] Due to the risk of chronic heartburn progressing to Barrett's, EGD every five years is recommended for people with chronic heartburn, or who take drugs for chronic GERD. [31]
Pantoprazole is used for short-term treatment of erosion and ulceration of the esophagus for adults and children five years of age and older caused by gastroesophageal reflux disease. [15] It can be used as a maintenance therapy for long-term use after initial response is obtained, but there have not been any controlled studies about the use of ...
Beyond glucose control and weight loss, benefits like a reduction in the risk of stroke, heart attacks, major cardiac events and kidney disease were expected, since some GLP-1 medicines have ...
Ranitidine has 10% of the affinity that cimetidine has to CYP450, so it causes fewer side effects, but other H 2 blockers famotidine and nizatidine have no CYP450 significant interactions. [ 131 ] Ranitidine was introduced in 1981, and was the world's biggest-selling prescription drug by 1987. [ 132 ]
2. Acute Kidney Injury. Some reports in a review supported by Novo Nordisk suggested that semaglutide may decrease the risk of kidney disease over the long term. But there were also a few reports ...