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MSI is a good marker for detecting Lynch syndrome and determining a prognosis for cancer treatments. In 1996, the National Cancer Institute (NCI) hosted an international workshop on Lynch Syndrome, which led to the development of the "Bethesda Guidelines" and loci for MSI testing.
Under the name constitutional mismatch repair-deficiency (CMMR-D), it has been mapped to MLH1, MSH2, MSH6 or PMS2. [2] Monoallelic mutations of these genes are observed in the condition known as Lynch syndrome or hereditary nonpolyposis colorectal cancer, while biallelic mutations are observed in CMMR-D. [3] People expressing the HNPCC (which itself is considered autosomal dominant) trait are ...
DNA mismatch repair protein Msh2 also known as MutS homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2.MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2, which forms a heterodimer with MSH6 to make the human MutSα mismatch repair complex.
The default map image, without "Image:" or "File:" image1 = Relief map of Texas.png An alternative map image, usually a relief map, which can be displayed via the relief or AlternativeMap parameters; top = 36.8 Latitude at top edge of map, in decimal degrees; bottom = 25.5 Latitude at bottom edge of map, in decimal degrees; left = -106.9 ...
On July 21, 2023, the OMB delineated 13 combined statistical areas, 26 metropolitan statistical areas, and 41 micropolitan statistical areas in Texas. [1] As of 2023, the largest of these is the Dallas-Fort Worth, TX-OK CSA , encompassing the area around the twin cities of Dallas and Fort Worth in the northern part of the state.
Highways in Texas; Interstate; US; State; Toll; Loops; Spurs; FM/RM; Park; Rec; Farm to Market Roads in Texas are owned and maintained by the Texas Department of ...
SpaceX McGregor engine test bunker, September 2012. SpaceX's Rocket Development and Test Facility in McGregor, Texas is a rocket engine test facility. Every rocket engine and thruster manufactured by SpaceX must pass through McGregor for rigorous final testing, ensuring their reliability and performance before being used on flight missions.
A map of FM 2134 in 1961. The road preceded RE 11. Only RE 2, RE 8, and RE 11 roughly followed the course of pre-existing routes. Recreational Road 11 connects FM 1929 to a recreational area on the O.H. Ivie Reservoir. The highway begins at an intersection with FM 1929, south of the O. H. Ivie Reservoir, as a two-lane, paved road.