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7-Hydroxymitragynine (7-OH) is a terpenoid indole alkaloid from the plant Mitragyna speciosa, commonly known as kratom. [2] It was first described in 1994 [3] and is a human metabolite metabolized from mitragynine present in the Mitragyna speciosa, commonly known as kratom. 7-OH binds to opioid receptors like mitragynine, but research suggests that 7-OH binds with greater efficacy.
Mitragynine is the most abundant active alkaloid in kratom. In Thai varieties of kratom, mitragynine is the most abundant component (up to 66% of total alkaloids), while 7-hydroxymitragynine (7-OH) is a minor constituent (up to 2% of total alkaloid content).
Mitragynine pseudoindoxyl is a rearrangement product of 7-hydroxymitragynine, an active metabolite of mitragynine. [1] Mitragynine pseudoindoxyl can be produced in the blood as a metabolite of 7-hydroxymitragynine. [2]
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[32] [11] [9] The alkaloids mitragynine and 7-hydroxymitragynine are responsible for many of the complex effects of kratom, [11] [9] but other alkaloids may also contribute synergistically. [32] The effects of both mitragynine and 7-HMG remain disputed despite substantial study. Both are partial agonists of the μ-opioid receptor.
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A 2019 systematic review and meta-analysis by Murrie et al. found that the ... 7-hydroxymitragynine, raubasine, and corynanthine; Morning glory and Hawaiian Baby ...