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  2. Anti-amyloid drugs - Wikipedia

    en.wikipedia.org/wiki/Anti-amyloid_drugs

    Aducanumab, sold under the brand name Aduhelm, is a monoclonal antibody designed to treat Alzheimer's disease. It is a monoclonal antibody that targets aggregated forms (plaque) of amyloid beta (Aβ) found in the brains of people with Alzheimer's disease to reduce its buildup. [10] It was developed by Biogen and Eisai. [11] Aducanumab is given via intravenous infusion. [5] Aducanumab was ...

  3. Tafamidis - Wikipedia

    en.wikipedia.org/wiki/Tafamidis

    Tafamidis, sold under the brand names Vyndaqel and Vyndamax, [5] is a medication used to delay disease progression in adults with certain forms of transthyretin amyloidosis. It can be used to treat both hereditary forms, familial amyloid cardiomyopathy and familial amyloid polyneuropathy , as well as wild-type transthyretin amyloidosis , which ...

  4. Wild-type transthyretin amyloid - Wikipedia

    en.wikipedia.org/.../Wild-Type_Transthyretin_Amyloid

    Wild-type transthyretin amyloid (WTTA), also known as senile systemic amyloidosis (SSA), [1] is a disease that typically affects the heart and tendons of elderly people. It is caused by the accumulation of a wild-type (that is to say a normal ) protein called transthyretin .

  5. List of therapeutic monoclonal antibodies - Wikipedia

    en.wikipedia.org/wiki/List_of_therapeutic...

    β-amyloid: Alzheimer's disease: Porgaviximab [28] mab: chimeric: Zaire ebolavirus glycoprotein: Ebola virus disease: Prasinezumab [26] mab: humanized: Alpha-synuclein: Parkinson's disease: Prezalizumab [41] mab: humanized: inducible T-cell co-stimulatory ligand (ICOSL) Priliximab: mab: chimeric: CD4: Crohn's disease, multiple sclerosis ...

  6. Amyloidosis - Wikipedia

    en.wikipedia.org/wiki/Amyloidosis

    Some medical treatments are associated with amyloid disease, but this is rare. [19] Amyloid-forming proteins aggregate into distinctive fibrillar forms with a beta-sheet structure. [19] [20] The beta-sheet form of amyloid is proteolysis-resistant, meaning it can not be degraded or broken down. [5]

  7. Which cardiovascular drugs may help lower dementia risk? - AOL

    www.aol.com/cardiovascular-drugs-may-help-lower...

    Taking medications like blood pressure and lipid-lowering drugs for more than 5 years is associated with a lower incidence of dementia, a new study has found.

  8. Semagacestat - Wikipedia

    en.wikipedia.org/wiki/Semagacestat

    Semagacestat (LY-450139) was a candidate drug for a causal therapy against Alzheimer's disease. It was originally developed by Eli Lilly and Elan , and clinical trials were conducted by Eli Lilly. Phase III trials included over 3000 patients, [ 2 ] [ 3 ] but in August 2010, a disappointing interim analysis, in which semagacestat performed worse ...

  9. Dopamine treatment destroys beta-amyloid plaques in ... - AOL

    www.aol.com/lifestyle/dopamine-treatment...

    Researchers say the hormone dopamine may be used as a treatment for Alzheimer's disease as it stimulates the production of an enzyme known to break down beta-amyloid via a mouse model.

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