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Studies of humans have found possible links between glyphosate and non-alcoholic fatty liver disease, metabolic syndrome, cirrhosis, and chronic kidney disease. Endocrine and...
Considering its massive presence, daily exposure to glyphosate could be considered a health risk for humans. Indeed, in 2015, the IARC (International Agency for Research on Cancer) classified glyphosate and its derivatives in Group 2A, as probable human carcinogens.
Due to its widespread use, glyphosate is continuously being studied for possible long-term effects in humans, animals, and the environment. For its part, the EPA conducted extensive investigations into glyphosate since its introduction in 1974.
This article reviews the risk assessment process for evaluating the potential of glyphosate to cause adverse effects on human health and aims to improve understanding of recent studies on its carcinogenicity.
This review summarizes to summarize current in vitro and epidemiological studies investigating the effects of GLY exposure on human health. Recent human cell studies have reported several GLY and GBH toxicological effects and have contributed to a better understanding of the deleterious consequences associated with their exposure.
Given the sparse nature of the new data, previously identified studies on exposure to glyphosate in children were included in our analysis of children’s exposure. The lowest average level of glyphosate exposure reported was 0.28 μg/L and the highest average exposure levels reported was 4.04 μg/L.
The human, animal and mechanistic evidence indicates that glyphosate cannot be considered as a potent DNA reactive tumour-initiating chemical, and that a risk assessment based on threshold toxicological reference values is scientifically valid (SCOEL 2013).