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Clofazimine was originally intended as an anti-tuberculosis drug but proved ineffective. In 1959, a researcher named Y. T. Chang identified its effectiveness against leprosy. After clinical trials in Nigeria and elsewhere during the 1960s, Swiss pharmaceutical company Novartis launched the product in 1969 under the brand name Lamprene.
ATC code J04 Antimycobacterials is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Optional treatment of lobomycosis is surgical excision. Full excision of the lesion is required for clinical success. Repeated cryotherapy may also yield favorable clinical response. While there yet appears no optional medical therapy, clofazimine has been effective in some cases with lobomycosis. [4] [10]
Ulcerative lesions caused by Mycobacterium ulcerans respond well to clofazimine. It also has some activity against M. tuberculosis and can be used as last resort therapy for the treatment of MDR tuberculosis. The most disturbing adverse reaction to clofazimine is a red-brown discoloration of the skin, especially in light-skinned persons.
Dapsone is commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. [4] It is also used to both treat and prevent pneumocystis pneumonia (PCP). [ 4 ] [ 10 ] It is also used for toxoplasmosis in people unable to tolerate trimethoprim with sulfamethoxazole .
[24] [25] Thalidomide has been used successfully in the treatment of Erythema nodosum leprosum, [26] and it was approved by the U.S. FDA for this use in July 1998. [27] According to a 2009 meta-analysis, there is some evidence of benefit for both thalidomide and clofazimine in the treatment of erythema nodosum leprosum. [28]
In the 1950s, dapsone was introduced. The search for further effective antileprosy drugs led to the use of clofazimine and rifampicin in the 1960s and 1970s. [125] Later, Indian scientist Shantaram Yawalkar and his colleagues formulated a combined therapy using rifampicin and dapsone, intended to mitigate bacterial resistance. [126]
16491 Ensembl ENSG00000177272 ENSMUSG00000047959 UniProt P22001 P16390 RefSeq (mRNA) NM_002232 NM_008418 RefSeq (protein) NP_002223 NP_032444 Location (UCSC) Chr 1: 110.67 – 110.67 Mb Chr 3: 106.94 – 106.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or K v 1.3, is a protein that in ...
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