Search results
Results from the WOW.Com Content Network
Cannabinol (CBN) is a mildly psychoactive phytocannabinoid that acts as a low affinity partial agonist at both CB 1 and CB 2 receptors.This activity at CB 1 and CB 2 receptors constitutes interaction of CBN with the endocannabinoid system (ECS).
Although CBN shares the same mechanism of action as other more well-known phytocannabinoids (e.g., delta-9 tetrahydrocannabinol or D9THC), it has a lower affinity for CB1 receptors, meaning that much higher doses of CBN are required in order to experience physiologic effects (e.g., mild sedation) associated with CB1R agonism.
Cannabichromene has been hypothesized to affect THC psychoactivity, though in vivo effects have not been demonstrated. [5] CBC acts on the TRPV1 and TRPA1 receptors, interfering with their ability to break down endocannabinoids (chemicals such as anandamide and 2-AG that the body creates naturally).
CB-13 (CRA13, SAB-378) [1] is a cannabinoid drug, which acts as a potent agonist at both the CB 1 and CB 2 receptors, but has poor blood–brain barrier penetration, and so produces only peripheral effects at low doses, with symptoms of central effects such as catalepsy only appearing at much higher dose ranges.
Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!
Costco has issued a recall for a cold and flu medication, sold at its stores at the end of 2024, over concerns of contamination.. The retail giant, in an advisory issued on Jan. 2, said Kirkland ...
The Heimlich maneuver is a first-aid method recommended by most health organizations, which uses abdominal thrusts to dislodge an obstruction from a person’s windpipe. Boy, 8, Saves Choking ...
11-Hydroxycannabinol (11-OH-CBN) is the main active metabolite of cannabinol (CBN), one of the active components of cannabis, [1] and has also been isolated from cannabis itself. [2] It is more potent than CBN itself, acting as an agonist of CB 1 with around the same potency as THC , but is a weak antagonist at CB 2 .