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Voclosporin, sold under the brand name Lupkynis, is a calcineurin inhibitor used as an immunosuppressant medication for the treatment of lupus nephritis. [ 2 ] [ 4 ] It is an analog of ciclosporin that has enhanced action against calcineurin and greater metabolic stability.
A meta-analysis of four randomized controlled trials comparing treatments of membranous nephropathy showed that regimes comprising chlorambucil or cyclophosphamide, either alone or with steroids, were more effective than symptomatic treatment or treatment with steroids alone in inducing remission of the nephrotic syndrome. [citation needed]
Bexagliflozin was approved in the United States under the brand name Brenzavvy in January 2023. [25] Canagliflozin is the first SGLT2 inhibitor to be approved for use in the United States. It was approved in March 2013, under the brand name Invokana and it was also marketed throughout the European Union under the same name. [26] [27]
Administration of anti-inflammatory medications (such as steroids or NSAIDs) to reduce active inflammation in the kidney. [ 43 ] If the patient is showing signs of kidney failure or end-organ damage , the treatment team may opt to utilize kidney dialysis temporarily (or permanently, in some severe cases) to decrease stress on the kidneys and ...
Treatment of DPGN depends on the severity of the disease. An optimal treatment for DPGN is immunosuppressive therapy. [11] Two common immunosuppressive drugs used to treat DPGN are cyclophosphamide (CYC) and mycophenolate mofetil (MMF) if the DPGN is caused by SLE. [12] CYC and MMF both preserve the renal function in patients with SLE and DPGN ...
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Inhibits DNA and to a lesser extent RNA synthesis, produces single and double strand breaks in DNA possibly by free radical formation. Germ cell tumours, squamous cell carcinoma, pancreatic cancer, non-Hodgkin's, pleural sclerosing and Hodgkin's lymphoma. Pulmonary toxicity, hypersensitivity, scleroderma and Raynaud's phenomenon. Bortezomib: IV, SC
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