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[58] [135] In clinical trials, bicalutamide-induced liver changes have usually been transient and have rarely been severe. [8] [58] Bicalutamide was discontinued due to liver changes (manifested as hepatitis or marked increases in liver enzymes) in clinical trials in 0.3% to 1.5% of patients, or approximately 1% overall.
[27] [13] Rarely, it has been associated with cases of serious liver damage, [10] serious lung toxicity, [3] and sensitivity to light. [28] [29] Although the risk of adverse liver changes is small, monitoring of liver function is recommended during treatment. [10] Bicalutamide is a member of the nonsteroidal antiandrogen (NSAA) group of ...
The risk of elevated liver enzymes and liver failure with bicalutamide appears to be much smaller than with high doses of CPA, [88] which is the most widely used antiandrogen in transgender women in Europe and elsewhere in the world. [110] [134] [135] However, only low doses of CPA are now recommended for use in transgender women. [136]
Notes: Additional cases of bicalutamide-associated adverse liver changes have been reported. These include 11 cases in a 2006 Spanish pharmacovigilance system report (including 1 case of hepatitis , 2 cases of cholestatic hepatitis , 1 case of jaundice , 4 cases of elevated liver enzymes , and 1 case of elevated bilirubin ; no deaths) [ 18 ...
Fatty liver disease happens when fat builds up in your liver. This can cause damage, inflammation, and other complications. There are two main types of fatty liver disease: Nonalcoholic fatty ...
• Elevated liver enzymes [b] Uncommon (0.1–1%) Immune system disorders and hypersensitivity reactions • Angioedema • Hives: Rare (<0.1%) or unknown Respiratory disorders • Lung disease [c] Skin and subcutaneous tissue disorders • Sensitivity to light: Hepato-biliary disorders • Liver toxicity [c
Fatty liver disease is known as a “silent disease” as it has few symptoms. In fact, you might have fatty liver disease and not even know it. You may not experience any symptoms at all until it ...
Nonalcoholic fatty liver disease is a common but often overlooked condition affecting 1 in 4 Americans. It results from fat buildup in the liver, which can lead to inflammation, scarring, and ...