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Weight loss drugs have been developed since the early twentieth century, and many have been banned or withdrawn from the market due to adverse effects, including deaths; other drugs proved ineffective. Although many earlier drugs were stimulants such as amphetamines, in the early 2020s, GLP-1 receptor agonists became popular for weight loss.
Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4] It sold modestly until the 1990s, when it was combined with phentermine and heavily marketed. [1]
Fen-phen (popular combination of fenfluramine and phentermine) 1997 Cardiotoxicity Fenclofenac: 1984 UK Cutaneous reactions; animal carcinogenicity. [3] Fenclozic acid: 1970 UK, US Hepatotoxicity. [3] Fenfluramine: 1997 European Union, UK, US, India, South Africa, others
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Top Prescription Weight Loss Pills. Anti-obesity medications (AOMs) date back to the 1940s — well before modern regulations from the FDA (U.S. Food and Drug Administration) (FDA) were in place ...
The sale of these drugs would be less of a problem if the price of the original drugs were not so high, Califf told reporters at a media roundtable. Novo Nordisk's and Eli Lilly's weight loss ...
Phenmetrazine has been used as an appetite suppressant for purposes of weight loss. [2] It was used therapeutically for this indication at a dosage of 25 mg two or three times per day (or 50–75 mg/day total) in adults. [2] Phenmetrazine has been found to produce similar weight loss to dextroamphetamine in people with obesity. [3]
On Oct. 5, 2023, researchers reported people taking GLP-1 agonists — the class of drugs that includes Ozempic and its sister drug Wegovy, which is approved for weight loss — may be at an ...
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