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Sarcopenia (ICD-10-CM code M62.84 [1]) is a type of muscle loss that occurs with aging and/or immobility. It is characterized by the degenerative loss of skeletal muscle mass, quality, and strength. The rate of muscle loss is dependent on exercise level, co-morbidities, nutrition and other factors.
Muscle-atrophy can be induced in pre-clinical models (e.g. mice) to study the effects of therapeutic interventions against muscle-atrophy. Restriction of the diet, i.e. caloric restriction, leads to a significant loss of muscle mass within two weeks, and loss of muscle-mass can be rescued by a nutritional intervention. [35]
Compared to traditional metrics, such as the body mass index (BMI), (which uses weight and height), BRI may improve predictions of the amount of body fat and the volume of visceral adipose tissue. Despite its common use, BMI can misclassify individuals as obese because it does not distinguish between a person's lean body mass and fat mass.
A follow-up to this study was the DIETFITS trial that compared a Healthy Low-Fat to a Healthy Low-Carbohydrate study with over 600 women and men. This landmark study tested whether there is a predisposition to success on one diet or the other based on either a potential genetic pattern or a metabolic condition known as insulin resistance. [9]
A 2021 clinical trial found that participants taking semaglutide lost an average of 14.9 percent of their body weight after 68 weeks, compared to 2.4 percent of those taking a placebo. What’s ...
The CRON-diet (Calorie Restriction with Optimal Nutrition) [1] is a nutrient-rich, reduced calorie diet developed by Roy Walford, Lisa Walford, and Brian M. Delaney. [2] The CRON-diet involves calorie restriction in the hope that the practice will improve health and retard aging, while still attempting to provide the recommended daily amounts of various nutrients. [3]
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Mild calorie restriction may be beneficial for pregnant women to reduce weight gain (without weight loss) and reduce perinatal risks for both the mother and child. [11] [12] For overweight or obese individuals, calorie restriction may improve health through weight loss, although a gradual weight regain of 1–2 kg (2.2–4.4 lb) per year may occur.