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Hepatic arterial infusion (HAI) is a medical procedure that delivers chemotherapy directly to the liver.The procedure, mostly used in combination with systemic chemotherapy, plays a role in the treatment of liver metastases in patients with colorectal cancer (CRC). [1]
Using a system of catheters and filters, PHP isolates the liver from the circulatory system and infuses a chemotherapeutic agent directly to the liver via the hepatic artery. The venous effluent from the liver is then filtered outside of the body and the filtered blood is returned into the jugular vein.
Intra-arterial chemotherapy: high dose chemotherapy is administered directly into the tumor-feeding arteries. [ 20 ] Portal vein embolization (PVE): delivery of embolic material into the portal vein feeding the lobe of liver containing the tumor(s) of interest to induce growth of the non-diseased lobe in order to have adequate liver function ...
TACE of liver tumors derives its beneficial effect by two primary mechanisms. [3] Most tumors within the liver are supplied by the proper hepatic artery, so arterial embolization preferentially interrupts the tumor's blood supply and stalls growth until neovascularization. Secondly, focused administration of chemotherapy allows for delivery of ...
By attaching a chemotherapy drug to an antibody, doctors are able to deliver more potent cancer-fighting medicines directly into tumor cells, all while causing fewer side effects.. The ...
Isolated limb perfusion (often used in melanoma), [71] or isolated infusion of chemotherapy into the liver [72] or the lung have been used to treat some tumors. The main purpose of these approaches is to deliver a very high dose of chemotherapy to tumor sites without causing overwhelming systemic damage. [ 73 ]
Radiation therapy is used to kill cancer cells; however, normal cells are also damaged in the process. Currently, therapeutic doses of radiation can be targeted to tumors with great accuracy using linear accelerators in radiation oncology; however, when irradiating using external beam radiotherapy, the beam will always need to travel through healthy tissue, and the normal liver tissue is very ...
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