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Worldwide prevalence rate of Parkinson's disease as of 2019. Epidemiological studies have shown lower age-related prevalence of Parkinson's disease in South Asians, with the rate of prevalence being around 52.7 per 100,000 as compared to a higher prevalence rate observed in populations with European origin, 108-257 per 100,000.
Parkinson's disease (PD), the second most common neurodegenerative disease after Alzheimer's disease, affects 1% of people over 60 years of age. [1] [2] [3] In the past three decades, the number of PD cases has doubled globally from 2.5 million in 1990 to 6.1 million in 2016. [4] [5] As of 2022, there are ~10 million PD cases globally. [6]
Consequently, as global life expectancy has increased, Parkinson's disease prevalence has also risen, with an estimated increase in cases by 74% from 1990 to 2016. [237] The total number is predicted to rise to over 12 million patients by 2040. [238] Some label this a pandemic. [237]
Parkinson disease cases also increased from 18 to 30 cases per 100,000 people per year. There was no increasing trend for women over the 30-year period, as reported in JAMA Neurology.
Studies have shown that a GLP-1 drug, exenatide, sufficiently crosses the blood-brain barrier in rodent models of Parkinson’s disease, leading to improvements in motor performance, behavior ...
The disease has many complications, including anxiety, dementia, and depression. [29] Parkinson's disease typically occurs in people over the age of 60, of whom about one percent are affected. [30] [31] The prevalence of Parkinson's disease dementia also increases with age, and to a lesser degree, duration of the disease. [32]
Parkinson-plus syndromes (PPS) are a group of neurodegenerative [1] diseases featuring the classical features of Parkinson's disease (tremor, rigidity, akinesia/bradykinesia, and postural instability) with additional features that distinguish them from simple idiopathic Parkinson's disease (PD). Parkinson-plus syndromes are either inherited ...
Estimated prevalence rates of depression vary widely according to the population sampled and methodology used, although depressive symptoms, irrespective of classically defined DSM criteria for depression, are present in 35% of patients [13] There is an increased risk for any individual with depression to go on to develop Parkinson's disease at ...
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