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Of the drugs that cause DIL, hydralazine has been found to cause a higher incidence. Hydralazine is a medication used to treat high blood pressure. Approximately 5% of the patients who have taken hydralazine over long periods of time and in high doses have shown DIL-like symptoms. [8] Many of the other drugs have a low to very low risk to ...
Prolonged treatment may cause a syndrome similar to lupus, which can become fatal if the symptoms are not noticed and drug treatment stopped. [13] Hydralazine is within the top three drugs that is known to induce systemic lupus and this adverse drug event is dose dependent yet significant.
What it looks like: Lupus, a chronic autoimmune disease that causes inflammation throughout the body, often presents with a red, butterfly-shaped rash across the cheeks and nose. It is usually ...
Second is a discoid rash, which is chronic rash in sun-exposed areas that are plaque-like or forms a sort of patchy redness and can scar. Finally, a general photosensitivity of the skin—essentially a catch-all category for other rashes that happen to sun-exposed areas—typically only lasting a couple of days.
Common symptoms include extreme fatigue, joint pain or skin rashes. In rare cases, the disease may lead to kidney or heart damage, or weaken the immune system so the body can’t fight off infections.
Can stress cause a rash? Stress can lead to a rash, such as hives, and it can exacerbate other rash-like skin conditions, Hu says. ... Or it may be related to lupus, Ziechner adds.
An example is hydralazine, a blood pressure-lowering drug that occasionally can produce drug-induced lupus erythematosus in certain individuals. This also appears to be the mechanism by which the anesthetic gas halothane can cause a life-threatening hepatitis, as well as the mechanism by which penicillin-class drugs cause autoimmune hemolytic ...
Patients with drug-induced lupus erythematosus typically have positive tests for anti-histone antibodies but do not have indications for anti-dsDNA antibodies. Patients with idiopathic systemic lupus erythematosus have both types of autoantibodies present in their blood. Thus, this test can be useful in distinguishing these two illnesses. [9]
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