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Thiamine, also known as thiamin and vitamin B 1, is a vitamin – an essential micronutrient for humans and animals. [1] [3] [4] It is found in food and commercially synthesized to be a dietary supplement or medication. [1]
Thiamine: Thiamine plays a central role in the release of energy from carbohydrates. It is involved in RNA and DNA production, as well as nerve function. Its active form is a coenzyme called thiamine pyrophosphate (TPP), which takes part in the conversion of pyruvate to acetyl coenzyme A in metabolism. [11] Vitamin B 2: Riboflavin
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Thiamine deficiency is a medical condition of low levels of thiamine (vitamin B 1). [1] A severe and chronic form is known as beriberi. [1] [7] The name beriberi was possibly borrowed in the 18th century from the Sinhalese phrase බැරි බැරි (bæri bæri, “I cannot, I cannot”), owing to the weakness caused by the condition.
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H 2 O + thiamine <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H + [5] Produced by a wide range of plants and bacteria. In these organisms, it is mainly responsible for salvage of thiamine pyrimidine from degradation products, rather than the breakdown of thiamine. [5] In bacteria, it stays inside their ...
Benfotiamine is dephosphorylated to S-benzoylthiamine by ecto-alkaline phosphatases present in the intestinal mucosa, and is then hydrolyzed to thiamine by thioesterases in the liver. [7] Benfotiamine is more bioavailable than thiamine salts, [ 8 ] providing higher levels of thiamine in muscle, brain, liver, and kidney.
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