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Genetic suppression therefore restores the phenotype seen prior to the original background mutation. [1] Suppressor mutations are useful for identifying new genetic sites which affect a biological process of interest. They also provide evidence between functionally interacting molecules and intersecting biological pathways. [2]
In biochemistry, in the biological context of organisms' regulation of gene expression and production of gene products, downregulation is the process by which a cell decreases the production and quantities of its cellular components, such as RNA and proteins, in response to an external stimulus.
Nonsense suppressors are a useful genetic tool, but can also result in problematic side effects, since all identical stop codons in the genome will also be suppressed to the same degree. Genes with different or multiple stop codons will be unaffected. SUP35, a nonsense suppressor identified by Wickner in 1994, is a prion protein.
Censorship, the suppression of public communication considered objectionable to the general body of people as determined by a government or media outlet; Suppression of dissent, occurs when an individual or group tries to censor, persecute or otherwise oppress the other party rather than communicate logically
The Mechanisms of Apoptosis Archived 2018-03-09 at the Wayback Machine Kimball's Biology Pages. Simple explanation of the mechanisms of apoptosis triggered by internal signals (bcl-2), along the caspase-9, caspase-3 and caspase-7 pathway; and by external signals (FAS and TNF), along the caspase 8 pathway. Accessed 25 March 2007.
In pharmacologic (supraphysiologic) doses, glucocorticoids, such as prednisone, dexamethasone, and hydrocortisone are used to suppress various allergic, inflammatory, and autoimmune disorders. They are also administered as posttransplantory immunosuppressants to prevent the acute transplant rejection and graft-versus-host disease .
Improved understanding will require, for example, comprehending more completely the historical antecedents of current social oppression; the commonalities — and lack thereof – among the various social groups damaged by social oppression and the individual human beings who make up those groups; and the complex interplay between and amongst ...
Immunosuppression is a reduction of the activation or efficacy of the immune system.Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.