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2. Huntingtin - Wikipedia

   en.wikipedia.org/wiki/Huntingtin

   Huntingtin (Htt) is the protein coded for in humans by the HTT gene, also known as the IT15 ("interesting transcript 15") gene. [5] Mutated HTT is the cause of Huntington's disease (HD), and has been investigated for this role and also for its involvement in long-term memory storage. [6]

3. Tetrabenazine - Wikipedia

   en.wikipedia.org/wiki/Tetrabenazine

   Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders.It is sold under the brand names Nitoman and Xenazine among others. On August 15, 2008, the U.S. Food and Drug Administration approved the use of tetrabenazine to treat chorea associated with Huntington's disease.

4. Huntington's disease - Wikipedia

   en.wikipedia.org/wiki/Huntington's_disease

   Huntington's disease (HD), also known as Huntington's chorea, is an incurable neurodegenerative disease [7] that is mostly inherited. [8] The earliest symptoms are often subtle problems with mood or mental/psychiatric abilities. [9] [1] A general lack of coordination and an unsteady gait often follow. [2]

5. Branaplam - Wikipedia

   en.wikipedia.org/wiki/Branaplam

   Branaplam (development codes LMI070 and NVS-SM1) is a pyridazine derivative that is being studied as an experimental drug.It was originally developed by Novartis to treat spinal muscular atrophy (SMA); since 2020 it was being developed to treat Huntington's disease but the trial ended in 2023 due to toxicity concerns.

6. CHDI Foundation - Wikipedia

   en.wikipedia.org/wiki/CHDI_Foundation

   The CHDI Foundation, Inc., is a United States–based non-profit biomedical foundation that aims to "rapidly discover and develop drugs that delay or slow the progression of Huntington's disease", [4] a neurodegenerative genetic disorder that affects muscle coordination and leads to cognitive decline.

7. Trinucleotide repeat disorder - Wikipedia

   en.wikipedia.org/wiki/Trinucleotide_repeat_disorder

   These often are translated into polyglutamine-containing proteins that form inclusions and are toxic to neuronal cells. Examples of the disorders caused by this mechanism include Huntington's disease and Huntington disease-like 2, spinal-bulbar muscular atrophy, dentatorubral-pallidoluysian atrophy, and spinocerebellar ataxia 1–3, 6–8, and 17.