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Raloxifene is a selective estrogen receptor modulator (SERM) and therefore a mixed agonist–antagonist of the estrogen receptor (ER). [6] It has estrogenic effects in bone and antiestrogenic effects in the breasts and uterus. [6] Raloxifene was approved for medical use in the United States in 1997. [6] It is available as a generic medication.
Ten Thousand Days (Hungarian: Tízezer nap) is a 1967 Hungarian drama film directed by Ferenc Kósa. It was entered into the 1967 Cannes Film Festival where Kósa won the award for Best Director. [1] The film was chosen to be part of the Budapest Twelve, a list of Hungarian films considered the best in 1968. [2]
The antiestrogen withdrawal response is a paradoxical improvement in breast cancer caused by discontinuation of antiestrogen therapy for breast cancer. [1] [2] [3] [4 ...
Estradiol was used as a positive control and raloxifene was used because it is in the same drug class as ospemifene. [10] Multiple doses of oral ospemifene were tested. [10] 10 mg/kg/day of Ospemifene was found to cause a greater increase in vaginal weight and vaginal epithelial height than 10 mg/kg/day of raloxifene. [10]
Lasofoxifene, sold under the brand name Fablyn, is a nonsteroidal selective estrogen receptor modulator (SERM) which is marketed by Pfizer in Lithuania and Portugal for the prevention and treatment of osteoporosis and for the treatment of vaginal atrophy, [1] [2] and the result of an exclusive research collaboration with Ligand Pharmaceuticals (LGND).
The elimination half-life of toremifene is 3 to 7 days in healthy individuals. [1] In people with impaired liver function , the half-life is 11 days. [ 1 ] The elimination half-lives of the metabolites of toremifene are 5 to 21 days for N -desmethyltoremifene, 5 days for 4-hydroxytoremifene, and 4 days for ospemifene.
20,000 Days on Earth is a 2014 British musical documentary drama film co-written and directed by Iain Forsyth and Jane Pollard. [3] [4] Nick Cave also co-wrote the script with Forsyth and Pollard. The film premiered in-competition in the World Cinema Documentary Competition at 2014 Sundance Film Festival on 20 January 2014.
Bazedoxifene, used as bazedoxifene acetate, is a medication for bone problems and possibly (pending more study) for cancer. [2] It is a third-generation selective estrogen receptor modulator (SERM). [3]