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Marble burying is an animal model used in scientific research to depict anxiety or obsessive–compulsive disorder (OCD) behavior. It is based on the observation that rats and mice will bury either harmful or harmless objects in their bedding. [1]
Individual rats would rarely eat except in the company of other rats. As a result extreme population densities developed in the pen adopted for eating, leaving the others with sparse populations. In the experiments in which the behavioral sink developed, infant mortality ran as high as 96 percent among the most disoriented groups in the population.
Epigenetics of anxiety and stress–related disorders is the field studying the relationship between epigenetic modifications of genes and anxiety and stress-related disorders, including mental health disorders such as generalized anxiety disorder (GAD), post-traumatic stress disorder, obsessive-compulsive disorder (OCD), and more.
It is difficult to develop an animal model that perfectly reproduces the symptoms of depression in patients. It is generic that 3 standards may be used to evaluate the reliability of an animal version of depression: the phenomenological or morphological appearances (face validity), a comparable etiology (assemble validity), and healing similarities (predictive validity).
The main strength of the tail suspension test is its predictive validity– performance on the test can be altered by drugs that improve depressive symptoms in people. Specifically, if antidepressant agents are administered before the test, the animal will struggle for a longer period of time than if not and exhibit more escape behaviors. [ 1 ]
The pit of despair was a name used by American comparative psychologist Harry Harlow for a device he designed, technically called a vertical chamber apparatus, that he used in experiments on rhesus macaque monkeys at the University of Wisconsin–Madison in the 1970s. [2]
Elderly Maine Coon cat resting on a bed, looking relaxed and comfortable. Image credits: southendpetsitting After 12 years in a rabbit cage and more time at a rescue shelter, Luna finally found ...
Group CC was isolated in laboratory cages when they were weaned at 22 days of age, and lived there until the experiment ended at 80 days of age; Group PP was housed in Rat Park for the same period; Group CP was moved from laboratory cages to Rat Park at 65 days of age; and Group PC was moved out of Rat Park and into cages at 65 days of age. The ...