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Autologous matrix-induced chondrogenesis (AMIC) is a treatment for articular cartilage damage.It combines microfracture surgery with the application of a bi-layer collagen I/III membrane.
Autologous cultured chondrocytes on porcine collagen membrane (Maci) is a treatment to correct cartilage defects in the knee. [1] It is used to treat symptomatic, full-thickness cartilage defects of the knee with or without bone involvement.
In biology, the extracellular matrix (ECM), [1] [2] also called intercellular matrix (ICM), is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells.
Semi-transparent and non-porous, it is usually covered by a tough and fibrous membrane called perichondrium. In tetrapods, it covers and protects the ends of long bones at the joints as articular cartilage , [ 1 ] and is a structural component of many body parts including the rib cage , the neck and the bronchial tubes, and the intervertebral ...
Type IV collagen is a main component of basement membranes in various tissues (arteries included). [ 13 ] Over the past decade, studies have repeatedly found single-nucleotide polymorphisms located in the collagen ( COL) 4A1 and COL4A2 genes to be associated with cardiovascular disease , and the 13q34 locus harboring these genes is one of the ...
Collagen based drug delivery systems: collagen films act like a barrier membrane and are used to treat tissue infections like infected corneal tissue or liver cancer. [8] Collagen films have all been used for gene delivery carriers which can promote bone formation.
Collagen alpha-1(IV) chain (COL4A1) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. [ 5 ] [ 6 ] It is ubiquitously expressed in many tissues and cell types. [ 7 ] COL4A1 is a subunit of the type IV collagen and plays a role in angiogenesis . [ 8 ]
Collagen alpha-1(VII) chain is a protein that in humans is encoded by the COL7A1 gene. [5] It is composed of a triple helical, collagenous domain flanked by two non-collagenous domains, and functions as an anchoring fibril between the dermal-epidermal junction in the basement membrane. [6]
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