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Stimulant use disorder is a type of substance use disorder where the use of stimulants caused clinically significant impairment or distress. It is defined in the DSM-5 as "the continued use of amphetamine -type substances, cocaine , or other stimulants leading to clinically significant impairment or distress, from mild to severe". [ 1 ]
Drugs in the class of amphetamines, or substituted amphetamines, are known to induce "amphetamine psychosis" typically when chronically abused or used in high doses. [8] In an Australian study of 309 active methamphetamine users, 18% had experienced a clinical level psychosis in the past year. [9]
Amphetamine dependence has shown to have the highest remission rate compared to cannabis, cocaine, and opioids. [9] Severe withdrawal associated with dependence from recreational substituted amphetamine use can be difficult for a user to cope with. [10] [11] [12] Long-term use of certain substituted amphetamines, particularly methamphetamine ...
At high doses, prescription amphetamines, used to treat ADHD could increase a person’s risk of psychosis. Image credit: visualspace/Getty Images.
The test can detect antipsychotic-like activity both in the case of dopamine D 2 receptor antagonists and in the case of drugs lacking D 2 receptor antagonism. [1] [2] [6] The occupancy of the D 2 receptor by antagonists of this receptor required to inhibit the CAR is around 65 to 80%, which is similar to the occupancy at which therapeutic antipsychotic effects occur in humans with these drugs.
After its discovery, amphetamine was purified and put into medical use in the 1900s. [5] Amphetamine was originally sold as a decongestant inhaler in the United States in 1933 and led to widespread ATS abuse in military forces and civilians later on. [5] The details of history of amphetamine can be found here.
Trimethoxyamphetamine (TMA or TMA-1), also known as 3,4,5-trimethoxyamphetamine (3,4,5-TMA), α-methylmescaline, or mescalamphetamine, is a psychedelic drug of the phenethylamine and amphetamine families. [1] [2] It is one of the trimethoxyamphetamine (TMA) series of positional isomers.
Mysterious “traffic” signs featuring former President Donald Trump’s silhouetted profile have been popping up around Staten Island, Bay Ridge and other parts of the city, garnering a mix of ...