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Cannabinoid receptor 1 (CB1), is a G protein-coupled cannabinoid receptor that in humans is encoded by the CNR1 gene. [5] And discovered, by determination and characterization in 1988, [6] and cloned in 1990 for the first time.
Cannabinoid receptor type 1 (CB 1) receptors are thought to be one of the most widely expressed G αi protein-coupled receptors in the brain. One mechanism through which they function is endocannabinoid-mediated depolarization-induced suppression of inhibition , a very common form of retrograde signaling , in which the depolarization of a ...
The logo for Charlie and the Chocolate Factory. This is a list of characters in the 1964 Roald Dahl book Charlie and the Chocolate Factory, his 1972 sequel Charlie and the Great Glass Elevator, and the former's film adaptations, Willy Wonka & the Chocolate Factory (1971), Charlie and the Chocolate Factory (2005), Tom and Jerry: Willy Wonka and the Chocolate Factory (2017), and Wonka (2023).
[4] [11] CB 1 antagonists produce inverse cannabimimetic effects that are opposite in direction from those produced by agonists for these receptors. [4] [16] CB 1 receptors are highly expressed in hypothalamic areas which are involved in central food intake control and feeding behavior. This strongly indicates that the cannabinoid system is ...
Anandamide binds to the central (CB 1) and, to a lesser extent, peripheral (CB 2) cannabinoid receptors, where it acts as a partial agonist. Anandamide is about as potent as THC at the CB 1 receptor. [76] Anandamide is found in nearly all tissues in a wide range of animals. [77] Anandamide has also been found in plants, including small amounts ...
For example, Δ 9-THC has an EC 50 of 250 nM at CB 1 and 1157 nM at CB 2, whereas PB-22 has an EC 50 of 5.1 nM at CB 1 and 37 nM at CB 2. [8] Adverse effects observed due to synthetic cannabinoid use include acute kidney injury, cardiac toxicity, seizure, stroke, tremor, hypokalemia, and rhabdomyolysis.
Making Good is a 1932 animated short film by Walter Lantz Productions, starring Oswald the Lucky Rabbit. [1] It is the 57th Oswald film by Lantz's studio and the 110th overall. The film had an original copyright notice, but it was not renewed.
A dried cannabis flower. The short-term effects of cannabis are caused by many chemical compounds in the cannabis plant, including 113 [clarification needed] different cannabinoids, such as tetrahydrocannabinol, and 120 terpenes, [1] which allow its drug to have various psychological and physiological effects on the human body.