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Periods when gout symptoms are more severe are called gout flares or gout attacks. A gout flare comes on suddenly, and symptoms are often intense. This will most commonly happen at night.
Without treatment, an acute attack of gout usually resolves in five to seven days; however, 60% of people have a second attack within one year. [16] Those with gout are at increased risk of hypertension, diabetes mellitus, metabolic syndrome, and kidney and cardiovascular disease and thus are at increased risk of death.
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Gout most often affects middle-aged and older men. In fact, men are three to 10 times more likely to have gout than women. However, younger men and women of all ages can have gout.
Gout can occur where serum uric acid levels are as low as 6 mg per 100 mL (357 μmol/L), but an individual can have serum values as high as 9.6 mg per 100 mL (565 μmol/L) and not have gout. [ 18 ] In humans, purines are metabolized into uric acid, which is then excreted in the urine.
Colchicine is a medication used to prevent and treat gout, [3] [4] to treat familial Mediterranean fever [5] and Behçet's disease, [6] and to reduce the risk of myocardial infarction. [7] The American College of Rheumatology recommends colchicine, nonsteroidal anti-inflammatory drugs (NSAIDs) or steroids in the treatment of gout.
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