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The dog leukocyte antigen (DLA) is a part of the major histocompatibility complex (MHC) in dogs, encoding genes in the MHC. The DLA and MHC system are interchangeable terms in canines. The MHC plays a critical role in the immune response system and consists of three regions: class I, class II and class III.
An immune response is a physiological reaction which occurs within an organism in the context of inflammation for the purpose of defending against exogenous factors. These include a wide variety of different toxins, viruses, intra- and extracellular bacteria, protozoa, helminths, and fungi which could cause serious problems to the health of the host organism if not cleared from the body.
Light microscopic video sequence of a neutrophil from human blood phagocytosing a bacterium. Neutrophils, macrophages, monocytes, dendritic cells, osteoclasts and eosinophils can be classified as professional phagocytes. [10] The first three have the greatest role in immune response to most infections. [11]
The adaptive immune system evolved in early vertebrates and allows for a stronger immune response as well as immunological memory, where each pathogen is "remembered" by a signature antigen. [55] The adaptive immune response is antigen-specific and requires the recognition of specific "non-self" antigens during a process called antigen ...
The immune system extends this response to its treatments of self-antigens, softening reactions against allergens, the body, [9] and digestive microorganisms. [15] As the worms developed ways of triggering a beneficial immune response, humans came to rely on parasitic interaction to help regulate their immune systems.
The polarization during primary exposure to an antigen is key in determining a number of chronic diseases, such as inflammatory bowel diseases and asthma, by skewing the immune response that memory Th cells coordinate when their memory recall is triggered upon secondary exposure to similar antigens.
Dogs are susceptible to allergies much like their human companions. Most allergies occur in dogs over 6 months old. A dog that is repeatedly exposed to a particular allergen becomes sensitized to it, and the immune system overreacts to a subsequent exposure, most commonly manifesting in the form of skin irritation. [1]
However, strictly speaking, immunogenicity refers to the ability of an antigen to induce an adaptive immune response. Thus an antigen might bind specifically to a T or B cell receptor, but not induce an adaptive immune response. If the antigen does induce a response, it is an 'immunogenic antigen', which is referred to as an immunogen.