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The innate immune system or nonspecific immune system [1] is one of the two main immunity strategies in vertebrates (the other being the adaptive immune system). The innate immune system is an alternate defense strategy and is the dominant immune system response found in plants , fungi , prokaryotes , and invertebrates (see Beyond vertebrates ).
Non-specific immunity, or innate immunity, is the immune system with which you were born, made up of phagocytes and barriers. Phagocytosis , derived from the Greek words phagein , meaning to eat, kytos or cell, and “osis” meaning process, was first described by Élie Metchnikoff , who won the Nobel Prize 100 years ago.
This is a list of immune cells, also known as white blood cells, white cells, leukocytes, or leucocytes. They are cells involved in protecting the body against both infectious disease and foreign invaders .
The complement system is part of the innate as well as the adaptive immune system; it is a group of circulating proteins that can bind pathogens and form a membrane attack complex. Complement deficiencies are the result of a lack of any of these proteins. They may predispose to infections but also to autoimmune conditions. [7]
1919 Jules Bordet (1870-1961), "for discovery of the complement system in the immune system" 1930 Karl Landsteiner (1868-1943), "for discovery of human blood types" 1960 Peter B. Medawar (1915-1987) and Frank Macfarlane Burnet (1899-1985), "for the discovery that the immune system of the fetus learns how to distinguish between self and non-self"
Trained immunity is a long-term functional modification of cells in the innate immune system which leads to an altered response to a second unrelated challenge. [1] For example, the BCG vaccine leads to a reduction in childhood mortality caused by unrelated infectious agents. [ 2 ]
Scheme of the complement system. The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. [1]
The function of the immune system primarily depends on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by CD4 helper T-lymphocytes , as well as through monocytes , macrophages , and endothelial cells.