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It is associated with the binding and unbinding reaction of receptor (R) and ligand (L) molecules, which is formalized as: R + L ⇌ RL. The reaction is characterized by the on-rate constant k on and the off-rate constant k off, which have units of M −1 s −1 and s −1, respectively. In equilibrium, the forward binding transition R + L → ...
When each receptor has a single ligand binding site, the system is described by [] + [] [] with an on-rate (k on) and off-rate (k off) related to the dissociation constant through K d =k off /k on. When the system equilibrates,
The consciousness and binding problem is the problem of how objects, background, and abstract or emotional features are combined into a single experience. [1] The binding problem refers to the overall encoding of our brain circuits for the combination of decisions, actions, and perception. It is considered a "problem" because no complete model ...
Receptor–ligand binding kinetics also involves the on- and off-rates of binding. A main goal of receptor–ligand kinetics is to determine the concentrations of the various kinetic species (i.e., the states of the receptor and ligand) at all times, from a given set of initial concentrations and a given set of rate constants.
The dissociation rate constant is defined using K off. [2] The Michaelis-Menten constant is denoted by K m and is represented by the equation K m = (K off + K cat)/ K on [definition needed]. The rates that the enzyme binds and dissociates from the substrate are represented by K on and K off respectively.
The symbol grounding problem is a concept in the fields of artificial intelligence, cognitive science, philosophy of mind, and semantics.It addresses the challenge of connecting symbols, such as words or abstract representations, to the real-world objects or concepts they refer to.
In coordination chemistry, a stability constant (also called formation constant or binding constant) is an equilibrium constant for the formation of a complex in solution. It is a measure of the strength of the interaction between the reagents that come together to form the complex. There are two main kinds of complex: compounds formed by the ...
The binding potential is then the ratio ligand-receptor complex to free ligand at equilibrium and in the limit of L tending to 0, and is given symbol BP: = | This quantity, originally defined by Mintun, [1] describes the capacity of a receptor to bind ligand. It is a limit (L << Ki) of the general receptor association equation: