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Hyperammonemia is a condition that happens when you have high levels of ammonia in your blood. It can be life-threatening and requires immediate medical treatment. Hyperammonemia has several causes. The two most common causes are liver disease and urea cycle disorders. Digestive Care.
Liver disease: Damage to your liver limits its ability to process ammonia. This often happens in severe liver disease, but you can have spikes in ammonia blood levels with stable liver disease, especially following a triggering event such as gastrointestinal bleeding or an electrolyte imbalance.
What Is Cirrhosis? Benefits of the Cirrhosis Diet. How the Cirrhosis Diet Works. What to Eat and Not Eat. When to Eat. A cirrhosis diet is designed to help people with cirrhosis who may become malnourished due to changes in their metabolism and digestion that occur as the liver becomes more damaged.
Liver Disease. Hepatic encephalopathy is a syndrome of neuropsychiatric manifestations in patients with liver disease, and one of the mechanisms of its development is hypothesized to be hyperammonemia. 10% of the patients with hepatic encephalopathy, however, do not have raised levels of ammonia.
Viral infections, autoimmune liver disease and acetaminophen poisoning are common causes. Cerebral edema, swelling in your brain, is a frequent side effect that may contribute to the effects of hepatic encephalopathy. Acute liver failure is an emergency and some cases may require a liver transplant.
High ammonia levels in your blood can be linked to many other liver conditions, such as hepatic encephalopathy, that are more easily treated when they’re detected early.
AASLD guidelines recommend that hepatic encephalopathy is a clinical diagnosis, stating “Increased blood ammonia alone does not add any diagnostic, staging, or prognostic value for HE in patients with CLD”. So, what do we do with this ammonia level?
High ammonia levels are most commonly caused by liver disease. The problem can also be caused by kidney failure and certain genetic disorders. This article discusses the symptoms and treatment of high ammonia levels.
High venous ammonia (VA) values have been proven to be a part of the mechanism of hepatic encephalopathy in patients with liver cirrhosis (LC) as well as acute hepatitis. Moreover, VA has been associated with poor prognosis and high mortality in these clinical settings.
High ammonia levels in the blood often indicate a problem with the liver. Doctors can provide treatment, including sodium benzoate and transplants. Learn more here.