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Helenalin, or (-)-4-Hydroxy-4a,8-dimethyl-3,3a,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione, is a toxic sesquiterpene lactone which can be found in several plants such as Arnica montana and Arnica chamissonis Helenalin is responsible for the toxicity of the Arnica spp.
The US Food and Drug Administration has classified Arnica montana as an unsafe herb because of its toxicity. [5] It should not be taken orally or applied to broken skin where absorption can occur. [5] Arnica irritates mucous membranes and may elicit stomach pain, diarrhea, and vomiting. [5] It may produce contact dermatitis when applied to skin ...
Arnica montana: Arnica: Used as an anti-inflammatory [23] and for osteoarthritis. [24] The US Food and Drug Administration has classified Arnica montana as an unsafe herb because of its toxicity. [25] It should not be taken orally or applied to broken skin where absorption can occur. [25] Astragalus propinquus: Astragalus: Long used in ...
"abdominal pain, diarrhea, potentially carcinogenic, with others can potentiate cardiac glycosides and antiarrhythmic agents" [3] Chaparral: creosote bush, gobernadora, larreastat [4] Larrea tridentata, Larrea divaricata [4] Liver damage, [3] [4] [5] kidney problems, [4] Hypotension in cancer patients [3] Chinese herbal mixtures: Heavy metal ...
There can be many years between promising laboratory work and the availability of an effective anti-cancer drug: Monroe Eliot Wall discovered anti-cancer properties in Camptotheca in 1958, but it was not until 1996 – after further research and rounds of clinical trials – that topotecan, a synthetic derivative of a chemical in the plant, was ...
Arnica latifolia is a species of arnica in the sunflower family, known by the common names broadleaf arnica, broad leaved arnica, mountain arnica, and daffodil leopardbane. [2] It is native to western North America from Alaska east to Northwest Territories and south to Mono County , California , and Taos County , New Mexico .
An individual plant can live 12 years, surviving periodic wildfire by resprouting from its long, slender rhizome afterward. [7] [8] The species could be confused with the similar Arnica latifolia, from which it can be distinguished by the leaves. The leaves of A. cordifolia are larger and heart-shaped.
As of 2019, only 32.9% of cancer patients in the United States died within five years of their diagnosis. [7] Despite their effectiveness, many conventional treatments are accompanied by a wide range of side effects, including pain, fatigue, and nausea. [8] [9] Some side effects can even be life-threatening.